Platelet-rich plasma (PRP) and autologous conditioned plasma (ACP), also known as fluid PRF, are both autologous treatments designed to support skin rejuvenation and tissue regeneration. Their methods of preparation and their biological profiles are distinct.
PRP (platelet-rich plasma) is a general term for blood-derived products that have a platelet concentration above baseline.6 PRP has been successfully used in aesthetic medicine, dermatology, and plastic surgery, as well as to promote healing in orthopedic medicine, sports medicine, trauma surgery, oral and maxillofacial surgery, and dentistry.3 PRP is produced by centrifuging a patient’s blood in a way that concentrates platelets within plasma. To preserve the fluid state and prevent clotting, anticoagulants are added during preparation.7 PRP is widely used and valued for its versatility and immediate availability of growth factors.
Fluid PRF (platelet-rich fibrin) represents a next-generation approach. Precise adjustments in centrifugation speed and duration allow for the separation of platelet-rich plasma without the need for anticoagulants. This results in a fluid formulation of PRF that retains a more natural composition and enables a gradual release of regenerative factors over time.7
Both PRP and ACP offer unique benefits, and the choice between them depends on the desired clinical outcome and treatment strategy. Practitioners can select the best option for each patient—whether they seek the immediate action of PRP or the sustained regenerative potential of fluid PRF.